Following her marriage and the birth of two children, Peter and Joan, she and her husband returned to Australia in 1926, where he found work as an agent for a printing press manufacturer.

[5] On the outbreak of World War II, Isaacson was made foreign news editor at The Age, but in July 1942 she joined in the Australian Women's Army Service.

Her work included accompanying women journalists and photographers on tours of military installations and acting as public relations officer to two generals, Thomas Blamey and Stanley Savige.

In 1945 she was appointed editor of the women's pages of The Argus, but in 1948 she bought, edited and wrote for The Dandenong Ranges News, which ceased publication in October 1949.

[6] In 1953 she became a director of her son's company, Peter Isaacson Publications She was posthumously inducted into the Australian Media Hall of Fame.