[2] The antiangiogenic effect may be an inhibition of basement membrane degradation.
These inhibitory agents prevent 'vascular invasion',[3] which is the proliferation of tumor cells in the blood or lymph vessels.
Their genetic transcription increases upon the expansion of cartilaginous regions.
[3] Recent studies on Troponin I[4] hypothesize that this protein performs its anti-proliferation effect on endothelial cells via interactions with a bFGF receptor.
[4] Neighboring studies on other anti-angiogenic factors are evolving, however, the general mechanism of action is still unknown today.