Once Big Bag left Cartoon Network's lineup in 2001, Baby Looney Tunes, along with Pecola, Sitting Ducks, and Hamtaro, filled that space in 2003.

[4][5] Tickle-U closed on January 13, 2006; some of its programmings still aired on Cartoon Network until 2007 and as part of the schedule of the British variation of Cartoonito.

On June 14, 2021, new idents of the block appeared on videos (which includes Esme & Roy, Mush-Mush & the Mushables, Care Bears: Unlock the Magic, and Love Monster) on Cartoonito's YouTube channel, and a newsletter was announced, with a new banner and avatar on the Cartoonito YouTube Channel in July.

[7][8] On August 16, 2021, the launch date was announced for September 13, 2021; Baby Looney Tunes would be the first show to air on the block.

Instead of the usual 6 a.m. time slot, Cartoonito would begin at 7 a.m. after a regular Cartoon Network program, retaining its 4 hours.

Currently, Cartoonito's lineup includes Bugs Bunny Builders, Batwheels, and Jessica's Big Little World; with Sesame Street exclusive to Max.