It is within the northern part of the Long Valley Caldera volcanic feature and zone, and beside U.S. Highway 395.

California State Route 203 branches off to the west from the Highway 395 interchange at Casa Diablo Hot Springs, leading to the Mammoth Lakes and ski resort area, and Devils Postpile National Monument.

It is noted as a Native American mining and manufacturing site specializing in obsidian materials.

Casa Diablo became a stage stop along the Bishop Creek to Bodie stagecoach route in 1878 (147 years ago) (1878).

In 1881, Casa Diablo stage station ceased operating and was later used for other business as a trading post, a seasonal resort, a tavern, a gas station, a grocery store, a hardware store and a lumber yard.