Casa Guazzoni is a building at via Malpighi 12 in Milan in the Liberty style, or Italian Art Nouveau.

The house was built in a part of the area previously occupied by Società Anonima degli Omnibus (S.A.O), founded in 1861 to manage public transportation in Milan with horse trams and which also had the concession of Tranvia Milano-Monza, inaugurated on 8 July 1876 by the future king Umberto I of Italy.

The building is made of a double body with the shape of an "L” on a trapezoidal lot and is located at the corner of via Malpighi with via Melzo.

It is characterized by a free treatment of the cement material and the application of exquisite wrought-iron united with a vivacious figurative sense.

Also in this case the balconies and the windows become lighter going upwards, just as the decorations become simpler towards the top floor: the dense twine of putti and wreaths, sculpted in cement around the windows and the railings of the first floor becomes simpler in the vibrant and sharp weave of the above iron work.

The driveway has a fine wrought-iron gate and frescoes with putti and flowers that were discovered in the restoration of 1997, probably by painter Paolo Sala.