It was designed in 1913 for Doña Isabel Oppenheimer-de Santiago[a] by one of Puerto Rico's foremost early 20th century architects, Alfredo Weichers.

[5] Mr. Weichers left Puerto Rico to study architecture in Barcelona, Spain, and returned to Ponce where he built various structures in the Spanish-Art Nouveau style.

Architecturally, the house is the result of an artful combination of elements from the contemporary modernist movement and the simpler townspeople's building traditions used in the hot southern coast of Puerto Rico.

"[7] The house is a raised, one-storey, brick and masonry residential structure on the northwest corner of Salud and Aurora streets, in Ponce's Historic Zone.

[2] The frontal facade consists of a concave shape and incorporates a podium porch, Ionic columns, a recessed loggia, and a cornice with a battlement parapet above.