Casa Sollievo della Sofferenza (English: "Home for the Relief of Suffering") is a private scientific research hospital in San Giovanni Rotondo, Italy, founded by Saint Pio of Pietrelcina, and administered by Vatican City.

The hospital has established Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies (ISBReMIT) that will be the first factory of GMP neural stem cells in Europe for producing bio-drugs and cell-drugs.

[6] Casa Sollievo della Sofferenza also houses a large out-patient clinic,[7] a hospital-school for the children suffering from cancer and other genetic disorders,[8] a reception centre which is a hotel complex,[9] and a social-assistance residence for elderly.

In front of Casa Sollievo della Sofferenza there is Sanctuary of Saint Pio of Pietrelcina, named after the founder of this hospital and research centre.

[2] Casa Sollievo della Sofferenza has taken an initiative to get into the activities of assistive robotics and artificial intelligence in the care sector in partnership with Konica Minolta Inc. and IIT - Istituto Italiano di Tecnologia.

[16] The Casa Sollievo della Sofferenza Hospital is an IRCCS (Istituto di ricovero e cura a carattere scientifico) research centre of Italian Ministry of Health, an institute of national interest, for "Genetic diseases, innovative therapies and regenerative medicine"[17] and received annual funding of 150 Million Euro in 2017.

Institute for Stem-Cell Biology, Regenerative Medicine and Innovative Therapies at Casa Sollievo della Sofferenza will also run non-profit clinical trials against sla, multiple sclerosis and glioblastoma.

It is working in collaboration with two innovative startups StemGen, Italy and HyperStem SA, Switzerland to revolutionize technology of cancer stem cells in experimentation on patients.

[25] In 2018, Oxford BioDynamics had signed a deal with Casa Sollievo della Sofferenza to develop a novel biomarker assay for Autism Spectrum Disorder (ASD).

[28] The aim of this unit is to study identification of early markers by non-invasive analysis, characterization of cancer stem cells, and develop customized molecular therapies.

[30] IRCCS Casa Sollievo della Sofferenza has been recognized as one of the 20 highly specialized centres for diagnosis and treatment of colorectal cancer based on studying genetic and molecular detail using microchip technology.

[34] Gilead Sciences, one of the world's largest biotech companies maintains strong collaboration with Casa Sollievo della Sofferenza for research on HCV treatment.

It has a well-annotated internal database of clinical and longitudinal data and biological samples for multiple genomic disorders, genetic and Mendelian diseases.

Built in 2002, this complex was a further step towards "Cittadella Ospedaliera", as desired by Saint Pio, the founder of Casa Sollievo della Sofferenza.

[39] Casa Sollievo della Sofferenza owns and runs two agritultural companies: Masseria Calderoso and Posta la Via.

The Masseria Calderoso farm extends over 71 hectares with about 9,400 olive trees of the Peranzana, Ogliarola Garganica and Rotondella varieties.

The farm produces extra virgin olive oil, strictly through biological production methods, which is used by the Casa Sollievo della Sofferenza Hospital and its associated facilities.