Casa de Estudillo was a 19th-century adobe house, located in San Leandro, California.

It was built by Don José Joaquín Estudillo, a member of the prominent Estudillo family of California.

It was built around 1850, and was the last home of José Joaquín Estudillo, a member of the prominent Estudillo family of California, and his wife Juana Martínez de Estudillo.

The site is now the location of St. Leander's Church.

The site of Casa de Estudillo is a California Historical Landmark.