Casa de Pedrorena, also called Altamirano-Pedrorena House is a historical Adobe building in San Diego, California, built in 1869.

In 1838, Miguel de Pedrorena arrived in San Diego Viejo.

Pedrorena's sister, Isabel de Altamirano, received the house in January 1871.

Jose Antonio Altamirano was born in 1835 in La Paz, Baja California.

Casa de Pedrorena is the newest and last of Old Town San Diego's adobe houses.