[3] With the purpose of presenting the history of Colombian currency, from the Colony to the Republican period, on July 20, 1961, the Bank of the Republic opened the doors of the Numismatic Museum on where it exhibited for the first time its extensive collection of coins and tickets.

At that time the museum had 1,032 pieces, including 400 two-escudo gold Santa Fereña macuquinas, minted between 1628 and 1636, found in the Magdalena River and known as the Tesoro del mesuno.

On 23 July 2023, and in commemoration of the Bank of the Republic centennial, the Museo Casa de Moneda re-opened to the public with a new permanent exhibition.

The first exhibition, Casa de Moneda Santafé, covers the history of the first mints of the Spanish Empire in the New World.

The museum itself is located within the Santafé de Bogotá Mint building, which was established by Philip III of Spain in 1620 to coin gold and silver that circulated in the New Kingdom of Granada.