It owes its name to the eight atlantes decorating its facade, termed "omenoni" ("big men" in Milanese), which were sculpted by Antonio Abondio,[1] most probably on a design by Leoni.
Artist and historian Giorgio Vasari expressed his admiration for the palace, stating that it was pieno [...] di capricciose invenzioni ("full of capricious inventions").
According to an inventory dating back to 1615, it had paintings by Titian, Parmigianino, and Michelangelo; the inventory also mentions a book of drawings by Leonardo da Vinci, which scholars identify with the Codex Atlanticus now preserved in the Biblioteca Ambrosiana.
[2][5] The palace has been largely restored and restructured in the 19th and 20th century; only the facade has remained almost unchanged, except for the addition of iron balconies and of the attic.
After being owned by Leone Leoni and then by his son Pompeo Leoni, the house was sold by Pompeo's son-in-law Polidoro Calchi, and over time was owned by several notable Milanese families, including the Belgioioso, the Pozzi, and the Besana.