[10] In 2014, DeSantis was a creator-moderator for The Chat, an hour-long round table panel discussion talk show that aired on Tegna's Jacksonville stations WTLV (NBC) and WJXX (ABC).

DeSantis wrote and produced the television documentary Champion, The JT Townsend Story about high school football player J.T.

[1] In 2018, Florida Politics called Casey "one of the most recognizable faces on Jacksonville television, with long runs at two local news operations.

DeSantis recognized Mary Ann Carroll, the only female member of the Highwaymen, as Florida's featured artist for the month.

[16] According to Politico, DeSantis has taken on a "sort of policy portfolio of her own that ranges from hurricane recovery to issues of mental health" in her role as First Lady.

[22][23] After receiving the Stateswoman of the Year award, speculation surrounding a potential bid by Casey DeSantis in Florida's 2026 gubernatorial election has emerged.

[27] They married on September 26, 2009,[28] at Walt Disney World Resort, which Ron DeSantis later called "kind of ironic" in the wake of his battle with the company over the Florida Parental Rights in Education Act.