[1] When Fedele reached fluency in Greek and Latin at the age of twelve, she was sent by her father to Gasparino Borro, a Servite friar, who tutored her in classical literature, philosophy, the sciences, and dialectics.

[1][3] In 1487, at twenty-two years of age, she achieved success in Italy and abroad when she delivered a Latin speech in praise of the arts and sciences at her cousin's graduation at Padua.

She participated with influential humanists in public debates on philosophical and theological issues and was asked to speak in front of the doge Agostino Barbarigo and the Venetian Senate on the subject of higher education for women.

After she married, and for almost sixty years, she wrote few letters and was invited only once, in 1556, to deliver a public address in honor of the Queen of Poland, Bona Sforza, who came to Venice.

She tried again in 1547 and wrote to Paolo III, who responded by giving her a position as the prioress of an orphanage at the church of San Domenico di Castello in Venice where she resided until her death.