The character made her live-action debut in the Marvel Cinematic Universe (MCU) film Deadpool & Wolverine (2024), portrayed by Emma Corrin.

[5] Despite this, the creature survived as chaotic cellular matter that clung to a sewer wall for decades, rebuilding its physical form and perfecting its effort to mimic human traits.

"[6] In reality, the mummudrai are a parasitic species born bodiless on the astral plane,[9] and it was only through becoming entangled with her brother's developing telepathic mind that Cassandra created a body for herself.

Cassandra then put herself into Xavier's machine Cerebra (an enhanced version of Cerebro) and switched minds with her brother before Emma Frost snapped her neck (as vengeance for her own students massacred in Genosha).

[14] Nova seemed to have returned in her original form in the "Danger" story arc of Astonishing X-Men, alongside Sebastian Shaw of the Hellfire Club.

[16] Emma and these manifestations then proceeded to attack the X-Men; Beast was reduced to a feral animal, Wolverine regressed to James Howlett as a timid child, Kitty Pryde lost control of her own phasing abilities, and Cyclops's powers disabled and rendered catatonic.

[17] Meanwhile, Emma/Cassandra utilized a cruel dystopic vision where Kitty gets tricked into using phasing powers to open the containment chamber where Cassandra, trapped in Stuff's form, had been imprisoned.

[20] Nova also had recruited the unwilling Forge to her cause and reveals that her mutant hatred is motivated by her near-death at the hands of her brother (that she had actually tried to kill first doesn't register with her).

She later reveals herself to Jean while the latter was using Searebro (the undersea Cerebro unit) to watch as the waves of anti-mutant hatred wash over the world and simultaneously sends also the unwilling Jamie Carlson aka Teen Abomination to smash Atlantis.

Emma and Kate were two of the mutants most impacted by Nova's horrific assault on Genosha, with all of Frost's young students dying in her arms and Pryde's human father being killed as well.

Kept alive but immobile and imprisoned in Threshold's "zero cells", Cassandra is left stranded 2 billion years in the past, with a mass extinction event on the horizon.

[23] When an incarnation of Brotherhood of Mutants, led by the ex-Acolyte Exodus, attempted to attack the institute, nurse Annie Ghazikhanian decided to leave the Mansion, along with her son Carter, as she felt the place was no longer safe.

[volume & issue needed][25] The projection was later revealed by Chuck Austen as the intended return of Cassandra Nova, but on his departure from the books, the storyline was dropped.

[citation needed] In an interview, Marvel writer Mike Carey stated that one of the more outlandish storylines he had considered involved Cassandra Nova and another mummudrai.

Alongside Wolverine, the three remaining Stepford Cuckoos (now calling themselves the Three-in-One), Beak's grandson Tito Jr, E.V.A., and No-Girl (Martha Johansson), Cassandra became one of the X-Men, fighting against Sublime and its armies of Crawlers, led by Apollyon.

[citation needed][30] However, this timeline diverged from Earth-616 when Jean Grey reached back and psychically forced Cyclops to accept Emma's offer to run the Xavier Institute together.

[volume & issue needed] Cassandra Nova factors prominently in the future depicted in X-Men: The End storyline as this version of the Phoenix.

In this timeline she remains a villain, primarily responsible for the Shi'ar attacks on the X-Men, which she had manipulated in the hopes of gaining control of Jean Grey and the Phoenix Force.

Bishop had been flung into this future Earth after failing in his attempt to kill Hope Summers and soon became a Revenant Hunter, even adopting a little girl named Amber.

The Revenant Queen intended to use Bishop as a vessel, for she wanted to travel back in time to set off the Great Corruption several thousand years earlier than it originally happened.

[35] Re-materializing in the present outside Union Station in Los Angeles, California, the Owl Queen directed Bishop's body towards finding a worthy psychic to sacrifice for the Corruption's rituals.

The Revenant Queen allowed the Demon Bear to run roughshod over the girl's defenders until she got close enough to project her own corrupted psyche into the child.

[37] During Secret Wars, the Westchester domain of Battleworld contained a version of Cassandra who ran the Clear Mountain Institute, the purpose of which was to condition formerly evil mutants into docile, non-violent people.

When the X-Men came to investigate, Cassandra's forces captured them, and she exposed them to the same treatment, seeking to transform them into "pure" and perfect role models for the children of Westchester.

In Joss Whedon's third arc of Astonishing X-Men, a psychic projection of Cassandra Nova seeks Stuff's gelatinous, green form, locked inside a metal case.