Cassibile (Sicilian: Cassìbbili) is an Italian village and civil parish (frazione) of the city and municipality (comune) of Syracuse (Siracusa), in Sicily.

The Necropolis of Cassibile, spread over the hills on either side of the Cassibile river, consists of hundreds of rock-cut chamber tombs dating to the Late Bronze and Iron Ages (about 1000–700 BC).

In 1850, he started the construction of the rural village, which was completed by his son Gaetano, who in 1870 built the church of the Holy Family.

The Cassibile River flows a few kilometres west of the village and includes a nature reserve along its course.

The A18, a partially built motorway that links Messina and Gela through Catania, Syracuse and Ragusa, serves the locality.