Vaughn has also played for the Indianapolis Colts, Detroit Lions, Baltimore Ravens and San Diego Chargers in the National Football League (NFL).

On October 9, 2011, in a 29–24 loss to the San Diego Chargers, Vaughn intercepted Philip Rivers' pass and returned it 55 yards for a touchdown.

[1] On November 9, 2012, Vaughn was fined $7,875 for a late hit on Miami Dolphins running back Reggie Bush in Week 9.

[11] During week 9, Vaughn secured a goal-line interception during a victory over the Montreal Alouettes which allowed the Argos to retake lead of the CFL East Division.

[12] The following week, the Argos lost to the Calgary Stampeders, 23–7, with Toronto's only points coming off of Vaughn's 3rd interception of the year, which he returned 115 yards for a touchdown.

[14] Vaughn finished the season with 32 tackles and 5 interceptions (which were returned for 209 yards and a score) during 16 games played, and was named a CFL East Division All Star.

[18] During 2018, Vaughn forced a fumble to create a short field and subsequent touchdown as part of Toronto's first victory in Week 4.