Castelnuovo di Val di Cecina is a comune (municipality) in the Province of Pisa in the Italian region Tuscany, located about 70 kilometres (43 mi) southwest of Florence and about 70 km southeast of Pisa.

Castelnuovo di Val di Cecina borders the following municipalities: Casole d'Elsa, Monterotondo Marittimo, Montieri, Pomarance, Radicondoli, Volterra.

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