It occupies the former valley of the Arno River (which now flows some km southwards), bounded by the Monte Pisano from north.

The Pieve di Santa Maria is a 12th-century parish church built in Romanesque style.

Vicopisano borders the following municipalities: Bientina, Buti, Calci, Calcinaia, Cascina and San Giuliano Terme.

[3] It counts the hamlets (frazioni) of Caprona, Cucigliana, Lugnano, Noce, San Giovanni alla Vena and Uliveto Terme.

Economical activities include ceramics, mechanics (Piaggio) and bottling of mineral waters.