The dominant position of the Castle on top of the Mountain Penna provided good protection in the ancient times.

In more recent times, the Lake Trasimeno nearby, a major touristic site, has long provided attraction to this place.

The several Etruscan cinerary urns were found in the walls of two houses located within the area of the Castle and along the hill in the 19th century.

Monte Sperello was part of the Byzantine line of defense against the Longobard attack, developed by the military administration of Perugia.

So in 997 it was donated by emperor Ottone III to the Benedictine monastery of San Gennaro di Campoleone [it] (today the Capolona in the province of Arezzo).

The nobility consortium, as a rule, included feudalism, and not from the point of view of a violent but peaceful conquest.

In 1439 the castle was rebuilt at the expense of Perugia which considered Montesperello one of its defensive landmarks towards the Trasimeno and the Arezzo area.

There are three paintings by artist Tedeschi Tito, which depict St. Francis, and buildings located in Assisi and Montesperello.

At 1 km to the north-east, at the foot of the hill, is the Autodromo dell'Umbria, an operating automobile and motorcycle circuit of the national level.

At the bottom of the southern slope is the winery Cantina Berioli,[13] surrounded by vineyards; there are meetings of winemakers in the region and wine-making events are held.