Caterina Anguissola Trivulzio (Piacenza, 1508 circa – Castel Goffredo, December 13, 1550) was an Italian noblewoman.

She was the daughter of Gian Giacomo Anguissola, of the line of Vigolzone, Count of Piacenza, and of Angela Radini Tedeschi.

After his death in 1549, Caterina governed, through Giovanni Anguissola,[4] the marquisate of Castel Goffredo, until the investiture of her son Alfonso in 1565.

Her beauty was exalted by humanist Lodovico Domenichi in his work La Nobiltà delle Donne.

[5] She died in Castel Goffredo in 1550[6] and was buried in the mausoleum of the Gonzaga family in Chiesa di Santa Maria del Consorzio.