Castelleone (Italian pronunciation: [kaˌstɛlleˈoːne]; locally Castigliòn) is a comune (municipality) in the Province of Cremona in the Italian region of Lombardy, located about 60 kilometres (37 mi) southeast of Milan and about 30 kilometres (19 mi) northwest of Cremona.

Castelleone borders the following municipalities: Cappella Cantone, Fiesco, Gombito, Izano, Madignano, Ripalta Arpina, San Bassano, Soresina, Trigolo.

Castelleone is served by the Castelleone railway station on the Treviglio–Cremona line.

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