Without an exact date, it is believed that the present building was consecrated and opened between 1761 and 1765.

It was in this cathedral that the new Argentine flag, created by Manuel Belgrano, was blessed on May 25, 1812.

Shortly thereafter, the troops and the population of the city, gathered in front of the Cabildo and swore loyalty before her.

This fact is today perpetuated by a painting by Luis De Servi, made for the centenary of the event and placed on one of the walls of the cathedral.

In it is venerated Our Lady of the Rosary of Paypaya and White River, declared in 1812 "Patron of the Armies of the North", used in the liberation of the country.