[3] The school was built on the site of old Calvary Cemetery, where leading families of Los Angeles were buried until relocated at the turn of the 20th century.

The school athletics teams are nicknamed the Phantoms because of its location on the old cemetery.

In 2023, their old track and field had been replaced with new grass and rubber ahead of the upcoming 100th year anniversary.

Cathedral High School has been the film location for a number of films, television shows, and music videos, due to its view of the Los Angeles skyline and character of its architecture, including the films City of Angels (1998), All You've Got (2006), Be Somebody (2016), North Hollywood (2021) the music video "I Do!!"

All You've Got used Cathedral's colors (purple and white) and name (Phantoms) for a volleyball team featured in the film.