Cathedral High School is an American all-girls', private, Roman Catholic high school in the borough of Manhattan in New York City, New York.

It is located within the Roman Catholic Archdiocese of New York.

[clarification needed] Enrollment is open to young women of all cultures and faiths.

There are plenty of college preparatory courses as well as Advanced Placement classes, including biology, calculus, English, history, literature, physics, and Spanish.

A course on religion is mandatory on an annual basis; however, the school accepts girls of all faiths.