Construction was begun in the late 13th century in Valencian Gothic style, with a Latin cross plan including a nave and two aisles, an ambulatory and chapels within buttresses.

The crossing, the late-Gothic great chapel, and the ambulatory are 15th century-early 16th century additions, including the removal of two pillars of the nave to obtain a taller vault at the crossing, after a design by Pere Compte.

There are three entrances: the Puerta de las Cadenas (Portal of the Chains, 14th century) is in Islamic style, the Puerta de Loreto (mid-15th century) is Gothic, and Gate of the Annunciation (at the north, built in 1588 by Juan Inglés), in Renaissance-style triumphal arch-shape.

Other Renaissance elements include the stalls and the grills of the choir, and the cloister (originally from 1377, but rebuilt until 1560).

Annexed to the church is a museum of Sacred Art, housing works by Diego Velázquez (Temptation of St. Thomas), Vicente López Portaña, José de Ribera, Juan de Juanes, Francisco Salzillo and other artists.