The Sisters of St. Joseph taught the girls and the commercial classes and the Christian Brothers taught the boys in the general classes under associate principalships held by Sr. Mary Angela and Brother Stanislaus respectively.

It was about the autumn of 1952 that the words to the "Crusader Song" were composed by Barry McIlhargey, a grade XII student and football player.

Joe Finn, a diocesan priest, took Brother Stanislaus' place as associate principal.

In 1967, CCHS and Catholic Central Separate School, which for a number of years held only grade IX and X students, were joined under one principalship, with Fr.

Conway as the first principle for grades IX-XIII A "tunnel" which was half above ground, was constructed to physically unite the two structures, which became known as the East Wing and the West Wing Owing to an increase in student population, a total of 14 portables were added between 1970 and 1972.

The north wing which accommodates the Fine Arts & Family Studies programs was constructed in 1986.

In 2013/2014 Catholic Central achieved the first "triple crown" in London since 1983, winning a TVRAA championship in football, hockey, and basketball.