The school's Troy property was put up for sale in March 2022, and was listed on the National Register of Historic Places in 2024.

Students at Catholic Central are encouraged to perform ten hours of community service.

The original Catholic Central High School building on Eighth St. has now become part of Rensselaer Polytechnic Institute.

In February, 1953, Catholic Central High School was relocated to its present-day campus in North Troy.

Busing was provided by the resident public school district for families within a fifteen-mile (24 km) radius.

Catholic Central High School educated students in grades 6–12 and offered a college preparatory/Regents curriculum along with the university at the High School program under the direction of the State University of New York at Albany.

The 2010–11 Girls Varsity Volleyball team won the Big 10 Championship and went on to the Section II semi-finals where they lost to Queensbury.

One year the parish school opened, staffed by the Sisters of the Presentation of the Blessed Virgin Mary.

Albany Catholic Schools Superintendent Giovanni Virgiglio said that considerations that affected the decision to move to St. Ambrose were the convenience of the location to the areas from which the school draws its students, and the fact that Lansingburgh was a split campus with students having to cross the street to get to the cafeteria and gymnasium.