She has worked on the AMC drama Mad Men and has won a Writers Guild of America (WGA) Award.
She co-wrote the first-season episode "Dead Man's Blood" with co-executive producer John Shiban.
She returned as a writer for the second season and wrote the episodes "The Usual Suspects" and "Born Under a Bad Sign".
Humphris joined the crew of AMC drama Mad Men as an executive story editor and writer for the third season in 2009.
Humphris and the writing staff won the Writers Guild of America (WGA) Award for Best Drama Series at the February 2010 ceremony for their work on the third season.