Cayuse is a census-designated place (CDP) and unincorporated community in Umatilla County, Oregon, United States, located 11 miles (18 km) east of Pendleton on the Umatilla Indian Reservation.

Served by a railroad station and post office, the area was named for the Cayuse people.

[6] According to the United States Census Bureau, the CDP has a total area of 2.9 square miles (7.5 km2), all land.

13.6% of all households were made up of individuals, and 13.6% had someone living alone who was 65 years of age or older.

There were 11.1% of families and 8.1% of the population living below the poverty line, including no under eighteens and 20.0% of those over 64.