Roth's father, Abrasha Rotenberg, is of Ukrainian Jewish origin, having moved in the 1930s to Buenos Aires, where he worked as a writer, editor, and journalist.

Roth has had great success in Spanish film since her first appearances in Las verdes praderas (The Green Meadows), by José Luis Garci; Arrebato (Rapture), by Iván Zulueta; and Laberinto de pasiones (Labyrinth of Passion) by Pedro Almodóvar.

Her most prominent movies include Un lugar en el mundo (A place in the world) and Martín (hache), both by Adolfo Aristarain.

In 1980 she worked with Almodovar on "Pepi, Luci, Bom" and, later, in "All About My Mother", which earned Almodóvar his first Academy Award for Best Foreign Language Film and “Pain and Glory”.

Roth has also made noteworthy appearances in numerous television series, including the soap operas Por amor (For love), together with Arnaldo André and Marita Ballesteros, and Nueve lunas (Nine moons).