Cecilia Verzellina (died 6 March 1660, Rome) was an Italian poisoner.
On 31 January 1659, Giovanna De Grandis was arrested and imprisoned in the Papal prison at Tor di Nona, where she made her confession on 1 February, and started to name the names of her accomplices and clients.
De Grandis stated that Cecilia Verzellina had asked to buy poison from her with the explicit purpose to poison the dyer Giovanni Pietro Beltrammi, who was the husband of her daughter, Teresa Verzellina.
Cecilia Verzellina had explained that her daughter lived in an unhappy marriage with a controlling mother-in-law and a jealous husband who abused her, and that she was worried that her daughter would be killed, because she had a lover, count Antonio Leonardi.
On 6 March 1660, Cecilia Verzellina was executed by hanging on Campo de' Fiori in Rome.