Cell division orientation

Abnormalities in the cell division orientation leads to the malformations during development and cancerous tissues.

[4] Cell division orientation is one of the mechanisms that shapes tissue during development and morphogenesis.

Oriented cell divisions contribute to the tissue elongation and the release of mechanical stress.

TCJ provide mechanical and geometrical clues for the spindle apparatus to ensure that cell divide along its long axis.

This stress could be the result of the external mechanical deformation of generated intracellularly by non-isotropic localization of specific proteins.

Cartoon of the dividing epithelium cell surrounded by epithelium tissue. Spindle apparatus rotates inside the cell. The rotation is a result of astral microtubules pulling towards tri-cellular-junctions (TCJ), signaling centers localized at the regions where three cells meet.