Centennial Collegiate Vocational Institute is a secondary high school located in ward five of Guelph, Ontario, Canada.

Centennial offers many programs including science, math, business, English, French, and biotechnology.

The school is located in the North East side of the city of Guelph, Ontario, Canada.

Centennial was opened in 1967, 100 years after Canadian Confederation, as indicated by its name and is operated by the Upper Grand District School Board.

[2] As of 2023, Centennial is ranked 35th out of 739 high schools in Ontario in the Fraser report.