The center is located in the Lakeview neighborhood on the corner of Halsted Street and Waveland, attached to Whole Foods Market.

Patrons participate in the diverse public programs and social services offered at Center on Halsted — ranging from volleyball and cooking classes to rapid HIV testing and group therapy.

After a $20-million capital campaign involving 2,000 donors, Center on Halsted opened its 175,000 sq ft (16,300 m2) Leadership in Energy and Environmental Design-certified building in 2007 with Whole Foods as an anchor tenant and two levels of underground parking.

These include: Center on Halsted works with city and state governments and an array of local providers to provide comprehensive social services to LGBT and ally community members in need including: The center works in collaboration with other Chicago nonprofits.

Center on Halsted also hosts a number of smaller community organizations in its space as Resident Partners.