In Lakeview Halsted passes through Wrigleyville, as intersecting with Addison Street, it is only two blocks east of Wrigley Field home of the Chicago Cubs.

South of a high bridge over the Eisenhower Expressway, Halsted forms the eastern border of the University of Illinois at Chicago.

Greektown and Maxwell Street business establishments continue to exist as remnants of the mass emigration of Southern Europeans, terminated by an act of Congress in 1924.

South of an underpass allowing Halsted to cross the BNSF Railway tracks at 16th street, parallel to the Dan Ryan Expressway, Halsted grazes the eastern edge of the Pilsen neighborhood, then crosses the Chicago River's south branch.

[1] Here Halsted Street enters Bridgeport, traditionally a working-class Irish, Lithuanian and Italian community, it has been home to five of the city's mayors.

Further south, Halsted intersects with 71st Street, which was honorarily named for Emmett Till, a victim of the violence of white supremacy in the United States.

Just south of 95th Street is the Carter G. Woodson regional branch of the Chicago Public Library.

The 359 Robbins/South Kedzie Avenue also runs along Halsted between 95th/Dan Ryan station and 124th Street before turning west.

[3] Professional wrestlers One Man Gang, Colt Cabana, Ace Steel, CM Punk, and Gary Hart have been billed from Halsted Street.

Nelson produced a film in 1934 traveling from the south end of Halsted Street to the North, across Chicago.