The new Centerpoint High School opened in August 1997 with Donis Smead serving as the first principal.

Those pathways include general curriculum, Honors and Advanced Placement (AP), Project 2020, and CAAST.

In August 2020, the Centerpoint Academy of Agriculture and Skilled Trades (CAAST) opened as a conversion charter school for students in grades 11–12.

Knight-Reddie ScholarshipStudents who graduate with honors from Centerpoint High School may choose to attend college at Henderson State University without paying tuition or fees.

The Knights sports teams include football, golf (boys/girls), basketball (boys/girls), baseball, softball, cross country (boys/girls), soccer (boys/girls), cheer, and track and field (boys/girls).