Centerville is a city in Reynolds County, Missouri, United States, situated along the West Fork of the Black River.

[5] A post office called Centreville was established in 1846, and the name was changed to Centerville in 1892.

[7] According to the United States Census Bureau, the city has a total area of 0.30 square miles (0.78 km2), all land.

Initially developed by ASARCO, it reached full production of 3,400 tons/day of ore in August 1988.

30.8% of all households were made up of individuals, and 18% had someone living alone who was 65 years of age or older.

The racial makeup of the city was 94.15% White, 3.51% Native American, and 2.34% from two or more races.

About 9.8% of families and 21.1% of the population were below the poverty line, including 56.0% of those under the age of eighteen and none of those 65 or over.