Centerville is a census-designated place (CDP) in Anderson County, South Carolina.

Interstate 85, the primary highway through Upstate South Carolina, is 4 miles (6 km) to the north at Exit 19.

[6] As of the 2020 United States census, there were 7,185 people, 2,990 households, and 1,870 families residing in the CDP.

There were 2,188 housing units at an average density of 372.2 per square mile (143.7/km2).

20.5% of all households were made up of individuals, and 6.6% had someone living alone who was 65 years of age or older.