Piedmont is a census-designated place (CDP) along the Saluda River in Anderson and Greenville counties in the U.S. state of South Carolina.

Henry Pinckney Hammett bought this property for his cotton mill that used water power of the shoals.

The American Civil War disrupted Hammett's project until 1876 when his plant began operations.

Water power from the Saluda River was also used to produce electricity to run the machinery from the 1880s to the 1920s.

Exit 35 on Interstate 85 is 2 miles (3 km) to the west of the center of Piedmont.

South Carolina state road 86 cuts through the small town also, connecting with Interstate 85 at Exit 35.

[5] The Saluda River flows southwards over a dam through the center of town.

As of the 2020 United States census, there were 5,411 people, 1,787 households, and 1,476 families residing in the CDP.