Pendleton is a town in Anderson County, South Carolina, United States.

Particularly notable historic buildings on the Pendleton town square include Farmer's Hall and Hunter's Store, which is currently the headquarters of the Pendleton District Historical, Recreational and Tourism Commission.

[6] After England claimed South Carolina as a colony, the Cherokee traded with the British.

[6] Andrew Pickens, who was a general in the Revolutionary War moved to the area and commissioned the District of Pendleton in 1790.

These homes were built as a summer vacation spot for the low-country plantation owners.

[7] The Ashtabula, Boone-Douthit House, Faith Cabin Library at Anderson County Training School, Pendleton Historic District, and Woodburn are listed on the National Register of Historic Places.

[9] Its northwestern edge touches the Anderson County/Pickens County line and borders the city of Clemson.

[5] As of the 2020 United States census, there were 3,489 people, 1,504 households, and 677 families residing in the town.