Diplomatic relations between the two states were established in 1967, but only in recent years they have been increasing their cooperation, with high level visits being made by Pope Francis and President Faustin-Archange Touadéra to each other's countries.

The Holy See maintains an apostolic nunciature in Bangui, while the Central African Republic has no diplomatic representation to Vatican City.

The most recent apostolic nuncio of the Holy See in CAR was Archbishop Franco Coppola (2014–2016),[1][2] but he was reassigned in the summer of 2016 and currently the position is vacant.

[4] Pope Francis made a visit to the Central African Republic in November 2015 and encouraged the country's process of national reconciliation, amidst the civil war that has been going on there.

[5] After being elected President of the Central African Republic, Faustin-Archange Touadéra visited Vatican City as his first international trip, in April 2016.