Central Medford High School (formerly Medford Opportunity High School) is a public alternative high school in Medford, Oregon, United States.

In 2020 the school relocated to its current location on Royal Avenue in Medford, occupying the previous location of Grace Christian campus - the old Oakdale Avenue campus now occupied by the new Oakdale Middle School.

John Kasich, 2016 Republican presidential candidate and Governor of Ohio, hosted a campaign event at the school on April 28, 2016.

Of 184 students, seven graduated, 148 dropped out, and 29 were still in high school the following year.

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