The CTSP was then founded in 2003, with the groundbreaking ceremony taking place on 28 July 2003 in conjunction with the construction of AU Optronics.

[6] Following ongoing disputes between environmental groups and the park, a Taiwan court ordered a temporary stop to expansion in 2011.

The Taiwan Environmental Protection Administration stated health studies had not eliminated worries about polluted runoff into nearby farmland.

[8] Central Taiwan Science Park Bureau debuted a new disaster warning system in 2019.

[9] In 2019, CTSP had six primary sectors: optoelectronics, semiconductors, biotechnology, precision machinery, computers and peripherals, and green energy.