The main university campus, Ciudad Universitaria de Caracas, was designed by architect Carlos Raúl Villanueva and it is considered a masterpiece of urban planning and was declared a World Heritage Site by UNESCO in 2000.

Given such harsh circumstances, the Rector of the Seminary, Francisco Martínez de Porras and the people of Caracas requested the royal court in Madrid the creation of a university in Venezuela (then part of the Viceroyalty of New Granada).

Until the end of the 18th century, the official papal and royal censorship on books was largely ignored in Venezuela, a situation which allowed the smuggling of the works by Rousseau, Voltaire, Diderot, Montesquieu, Locke, Helvetius, Grotius in the ships belonging to the Guipuzcoana Company.

Gómez stayed in power until his death in 1935 and during this time, having ambivalent feelings about the purpose of educating free minds when he could hire foreigners to exercise any technical requirements for the nation, decided to close the university from 1912 to 1922.

This group, which shared a common front against Gómez, was conformed by people like Rómulo Betancourt, Miguel Otero Silva, Juan Oropeza, Isaac Pardo and Rodolfo Quintero.

The university continued to be at the forefront of the democratization of the country when in 1936, then President Eleazar López Contreras, ordered a decree suspending the Constitutional rights and declaring a general censorship of the press because the oil workers decided to start a strike (an unprecedented deed at the time).

Villanueva worked with 28 avant-garde artists of the time, from Venezuela and the rest of the world, to build what continues to be one of the most successful applications of Modern Architecture in Latin America.

Among some of the most important pieces present in the university are the 1953 Floating Clouds by Alexander Calder, murals by Victor Vasarely, Wifredo Lam, Fernand Léger and sculptures by Jean Arp and Henri Laurens.

The Ciudad Universitaria de Caracas was declared World Heritage by UNESCO, and it is the only modern university campus designed by a single architect to receive such high honor.