Centreville was a city in St. Clair County, Illinois, United States.

26.8% of all households were made up of individuals, and 11.8% had someone living alone who was 65 years of age or older.

Some of the city was served by Cahokia Unit School District 187.

[12] Some of the city was served by East St. Louis School District 189.

The town median household income was $17,441, while the typical home in the area is worth approximately $47,900.

[15] The city was located on a Mississippi River floodplain known as American Bottom, and experiences chronic flooding and raw sewage disposal problems due to the area's inadequate system of drainage ditches, levees and emergency pumps.