Centrifugal partition chromatography consists of a series-connected network of extraction cells, which operates as elemental extractors, and the efficiency is guaranteed by the cascade.
Centrifugal partition chromatography was introduced in Japan in 1982; the first instrument was built at Sanki Eng.
In 2017 RotaChrom designed its top performing CPC cells through computed fluid dynamic simulation software.
When entering the flow of mobiles phase forms small droplets according to the Stokes' law, which is called atomization.
These droplets fall through the stationary phase, creating a high interface area, which is called the extraction.
[4] Due to the ability to get very high selectivity, and the ability to tolerate samples containing particulated matter, it is possible to work with direct extracts of biomass, opposed to traditional liquid chromatography, where impurities degrade the solid stationary phase so that separation become impossible.
There are numerous laboratory scale centrifugal partition chromatography manufacturers around the world, like Gilson (Armen Instrument), Kromaton (Rousselet Robatel), and AECS-QUIKPREP.
Centrifugal partition chromatography does not use any solid stationary phase, so it guarantees a cost-effective separation for the highest industrial levels.
Industrial instruments have flow rates of multiple liter / minutes, while able to purify materials from 10 kg to tonnes per month.