The Centro Direzionale di Milano is a business district (quartiere) in Milan, Italy, part of the Zone 9 administrative division.

Coherently with this plan, the district is mainly occupied by modern office buildings, including several of Milan's skyscrapers.

A relevant part of the design effort focused on the realization of adequate infrastructures supporting heavy daily commute, although only some of the corresponding projects were actually implemented.

The main transportation hub in the area is Porta Garibaldi railway station, with connection to the Milan Metro, the suburban network and national rail lines.

Overall, the realization of the new district took place between 1955 and 1962, but was later suspended as a consequence of the lack of an actual regulation preventing tertiary activities to be established in the city centre.