During Napoleonic rule, in 1808, Villapizzone was annexed to Milan, but regained its autonomy in 1816 with the establishment of the Kingdom of Lombardy–Venetia.

The core of the village was the parish church of San Martino, in front of which was built a villa, owned by the noble Radice Fossati family.

A woodland, which was initially a portion of the ancient Bosco della Merlata, was located in the area, and some of the trees that belonged to the forest are now beside of Via Paolo Mantegazza, in what is now the yard of the Goffredo Mameli elementary school.

The toponym "Villapizzone" itself was scarcely used for several decades; it reappeared in the late 20th century as a consequence of the construction of the station of the same name.

Several tram and bus lines connect Villapizzone to the city center and to nearby suburbs.