Centrolene muelleri is a species of frog in the family Centrolenidae.

It is endemic to Peru and is known from the divide between the Huallaga and Marañón drainages, in the San Martín and Amazonas departments.

[1][2] The specific name muelleri honors Paul S. Müller, professor from Saarland University who supported Schulte's field work in Peru.

[3] Centrolene muelleri occurs in cloud forest at elevations of 1,830–2,050 m (6,000–6,730 ft) above sea level and in associated with streams.

Calling males have been observed on the upper surfaces of leaves 0.5–2.5 m (2–8 ft) above the water.