The store was evacuated after the first plane hit the World Trade Center, and the interior was significantly damaged from the collapse of the Twin Towers.

[7][8] The firm opened its first location outside of the greater New York metropolitan area in October 2014, housed on two floors of the former Strawbridge's flagship on Market Street in Center City, Philadelphia.

[16] In April 2018, the company opened a Century 21 EDITION pop-up store at the Staten Island Mall, focusing on high-end women's accessories.

[17] In July 2019, Century 21 announced plans to open a new location at the Roosevelt Field Mall in Garden City, New York in 2021.

[18] In February 2020, Century 21 announced plans to open a permanent location at the Staten Island Mall, taking over the lower level of the former Sears Store.